Over the years, L’Oréal’s Research and Innovation department has partnered with a number of academic, public and private institutions to advance the science of animal-free safety evaluation.
COSMETICS EUROPE - Europe. Cosmetics Europe, previously Colipa, has been the professional association of Europe’s cosmetic, toiletry and perfumery industry since 1962, and represents more than 2000 companies ranging from major international cosmetics manufacturers to small businesses. Cosmetics Europe plays a leading role in supporting the development, scientific and political acceptance and finally the use of alternative testing methods.
ECVAM, European Centre for the Validation of Alternative Methods - Europe. The European Centre for the Validation of Alternative Methods (ECVAM) promotes the scientific and regulatory acceptance of non-animal tests. In many industry sectors, reliance on animal test procedures is being progressively reduced. ECVAM coordinates independent evaluation of the relevance and reliability of tests for specific purposes in areas of biologicals, chemicals, agrochemicals and pharmaceuticals.
ECOPA, European Consensus Platform for Alternatives - Europe. Economic Policy Analysis (ECOPA) is committed to providing specialised economic consulting on countries and regions undergoing economic change. ECOPA offers its high value-added services to governments and funding agencies and businesses.
EPA TOX21 initiative - USA. Tox21 is pooling federal resources and expertise from the Environmental Protection Agency (EPA), National Institute of Environmental Health Sciences/National Toxicology Program, National Institute of Health and the Food and Drug Administration to use robotics technology to screen thousands of chemicals for potential toxicity, use screening data to predict the potential toxicity of chemicals and develop a cost-effective approach for prioritizing the thousands of chemicals that need toxicity testing.
EPAA, European Partnership for Alternative Approaches to Animal Testing - Europe. The European Partnership for Alternative Approaches to Animal Testing (EPAA) is an unprecedented voluntary collaboration between the European Commission, European trade associations, and companies from seven industry sectors. The partners are committed to pooling knowledge and resources to accelerate the development, validation and acceptance of alternative approaches to further the replacement, reduction and refinement (3Rs) of animal use in regulatory testing.
EUROPEAN UNION FRAMEWORK PROGRAMS FOR THE ALTERNATIVE METHODS DEVELOPMENT - Europe. The EU Framework Programmes for Research have two main strategic objectives: to strengthen the scientific and technological base of European industry and to encourage its international competitiveness, while promoting research that supports EU policies.
JACVAM - Japan. JACVAM’s mission is to promote the reduction, refinement and replacement (the 3Rs) of animal testing for the evaluation of chemical substance safety in Japan and establish guidelines for new alternative experimental methods through international collaboration.
OECD. The OECD (Organization for Economic Cooperation & Development) has contributed towards having more integrated approaches to testing and safety assessment. Integrated approaches are used in the OECD Existing Chemicals Programme which generates internationally agreed initial hazard assessments of chemicals. This practical application of integrated approaches improves their regulatory acceptance and facilitates their implementation into national and regional chemical assessment schemes in OECD member countries.
SENS-IT-IV, European Commission, European Union 6th Framework Programme. The overall objective of SENS-IT-IV is to produce in vitro alternatives for these assays, and develop them up to the level of pre-validation. Besides reducing animal experimentation, an increase the accuracy of predicting sensitising potencies is expected.
SEURAT-1. Safety Evaluation Ultimately Replacing Animal Testing is a Research Initiative financed by the European Commission and Cosmetics Europe that focuses on the complex challenges of repeated dose toxicity and the development of technological solutions for the replacement of current repeated dose systemic toxicity testing for the assessment of safety.
THE BURGAS PROF. ASSEN ZLATAROV UNIVERSITY, LABORATORY OF MATHEMATICAL CHEMISTRY, M. Todorov, O. Mekenyan - Burgas, Bulgaria. The major impact of LMC in Structure-Activity and Structure-Property modeling could be summarized as follows: building IT for structure complexity evaluation (conformer flexibility and metabolic transformations), assessing molecular reactivity and interaction mechanisms, building probabilistic QSAR models, evaluating model applicability domains, selecting chemicals for strategic testing, 3D databasing.
INSTITUTE FOR IN VITRO SCIENCES Inc, Gaithersburg, MD, A. Hilberer, H. Raabe, N. Wilt - USA. The Institute for In Vitro Sciences, Inc. is a non-profit research and testing laboratory dedicated to the advancement of in vitro (non-animal) methods worldwide. Founded in 1997, IIVS has worked with industry, academic laboratories and government agencies to implement in vitro testing strategies that limit animal use while supplying key information for product safety and efficacy decisions.
INSTITUT PASTEUR DE LILLE, F. Nesslany, D. Marzin - Lille, France. The Institut Pasteur de Lille (Pasteur-Lille) is a research centre, membre of the Pasteur Institute network. It includes 14 research units, 1150 employees including 626 researchers located in Lille (France). 300 employees located outside the Pasteur site come in addition. Its revenues are above 70 million Euros. Several start-up companies in neuro-sciences have emerged from the Institut Pasteur de Lille.
LAVAL UNIVERSITY HOSPITAL RESEARCH CENTER, Oncology and Molecular Endicronology Research Center - Quebec, Canada. Research is one of CHUQ’s four core missions. Focusing on innovation and excellence, it is tightly interwoven with CHUQ’s three other core missions, including the evaluation of health technologies and intervention methods (ETMIS). CRCHUQ’s research mission aims to advance knowledge with a view to developing practical methods for improving healthcare and promoting health and quality of life.
THE OHIO STATE UNIVERSITY, J.F. Rathman - Columbus, Ohio, USA. The Ohio State University’s main Columbus campus is one of America’s largest and most comprehensive. More than 55,000 students select from 14 colleges, 175 undergraduate majors, and 240 master’s, doctoral, and professional degree programs. As Ohio’s best and one of the nation’s top-20 public universities, Ohio State is further recognized by a top-rated academic medical center and a premier cancer hospital and research center.
THE RUTGERS UNIVERSITY - New Jersey, USA. Rutgers, the State University of New Jersey, is a leading national public research university and the state’s preeminent, comprehensive public institution of higher education. Rutgers is dedicated to teaching that meets the highest standards of excellence; to conducting research that breaks new ground; and to turning knowledge into solutions for local, national, and global communities.
PRIVATE SECTOR PARTNERSHIPS
ALTAMIRA LLC, C. Yang, J.F. Rathman - Ohio, USA. Altamira shares expertise in molecular informatics, chemometrics, computational modeling and analysis and statistical design of experiments. The two founders also provide many years of expertise in nano-structured materials and interfacial meso-scale modeling.
CEETOX - USA. CeeTox’s robust, systems-biology approach has developed in vitro models with real predictive power. It helps identify new drug candidates, chemicals, cosmetics, and consumer products that have the lowest risk for toxicity and the highest probability of success. CeeTox helps bring safer products to market.
HUREL CORPORATION - USA. HμREL® will establish and maintain its products and services as the pre-eminent technological substitute for animal testing, and the pre-eminent experimental platform for generating in vitro cell-based data of superior predictive relevance to the human organism.
IMMUNOSEARCH, F. Cottrez, H. Groux - France. ImmunoSearch is a leading European CRO company providing Research in Immuno-toxicology and Toxicologic Tests in a GLP environment for the perfume and cosmetic industry.
NIKODERM RESEARCH Inc - Japan. Nikoderm Research Inc. is offering a wide range of tests and other technical support for cosmetic and pharmaceutical products, as well as their components. Its purpose is to provide our customers with advanced safety and efficacy tests, based on the most up-to-date knowledge in cosmetology and dermatology.
OROXCELL - France. At Oroxcell, teams are actively committed to bringing top level partnership and services to biotech / pharmaceutical, cosmetic, food, veterinary and home products / chemicals industries in carrying out physico-chemical and ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) studies. Its integrated platform can provide quality or mechanistic studies to better understand product fate when in contact with an organism, but also in compliance with GLP to answer regulatory requirements.
WATCHFROG - France. WatchFrog creates and markets innovative solutions for the in vivo detection of a wide range of chemical, pharmaceutical and cosmetic substances. WatchFrog offers biotechnological tools to accelerate environmental risk assessment.